The Unique Effects of THCv

Weederall. 

Diet weed. 

The sports car of weed. 

These nicknames – all attributed to THCv (tetrahydrocannabivarin) – could be the most appealing nicknames ever given to a cannabinoid. Their implications certainly explain the surging interest in THCv, which is currently the most expensive cannabinoid in the market. 

So, what is THCv, and what makes THCv special? 

First discovered at the University of Oxford in 1970, THCv is a homolog of delta-9 THC, but its effects generally differ from its chemical cousin. Most people associate delta-9 with relaxation, drowsiness and the “munchies,” but THCv appears to boost energy, decrease appetite and increase satiety. Early studies indicate potential benefits such as weight loss, reduced glucose intolerance, lower fasting plasma glucose, improved pancreatic function, elevated responses to food reward, and increased bone growth and collagen production. 

To quote the Journal of Cannabis Research, “The uniquely diverse properties of THCv provide neuroprotection, appetite suppression, glycemic control, and reduced side effects, etc.; therefore, making it a potential priority candidate for the development of clinically useful therapies.” 

Potential benefits like energy, focus and appetite suppression would position THCv uniquely among cannabinoids. If proven effective, THCv could offer a plant-based alternative to medications like Ozempic, Adderall, Ritalin and Zepbound. 

While THCv exhibits many distinctive effects, it also shares some similarities with other cannabinoids, surprisingly aligning more with CBD than delta-9 THC in many ways.

For instance, delta-9 stimulates the CB₁ receptor for euphoric highs, but low-dose THCv – similar to CBD – can limit CB₁ activity and potentially reduce the euphoric effects of delta-9. Likewise, THCv helps to counteract the side effects of excessive delta-9 consumption, such as anxiety, paranoia and increased heart rate. However, at higher doses, THCv acts more like delta-9 by stimulating CB₁ receptors.

THCv also increases endocannabinoid levels. The body produces natural endocannabinoids like anandamide, and THCv delays their reabsorption into the body. Anandamide binds to both CB₁ and CB₂ receptors and produces a sense of bliss. THCv, like CBD, also appears to interact with 5-HT1A serotonin receptors associated with mental health. 

Similarities with other cannabinoids extend to potential therapeutic targets, such as psychosis, Parkinson’s, pain, epilepsy, fatty liver disease, bacterial inflammation and even acne.  

As cannabis farming and legal hemp practices advance, the cost of THCv is expected to decrease. Leveraging the right cannabinoid combinations, such as KANHA’s LOVE gummy with delta-9 THC (10mg), CBG (5mg), and THCv (5mg), can maximize the entourage effects for optimal experiences. 

Stay tuned for more cutting-edge formulas on the horizon!